Downloadable resources
Caregiver Brochure
Download this informative brochure with useful information about KHINDIVI.
Eton Cares
Download this quick reference guide for Eton Cares services and steps to support treatment success.
Storage and handling
Just follow a few simple steps to use and store KHINDIVI the right way
Administer as prescribed
Always give KHINDIVI exactly as your doctor has prescribed to help ensure accurate dosing
Store with convenience
No need for refrigeration, mixing, or shaking. Each bottle of KHINDIVI should be used within 120 days of receipt. Throw away any KHINDIVI that has not been used within this time frame
Keep it safe
Ensure the bottle is securely closed after each use and out of reach of children to avoid accidental spills or misuse
Keep it dry
Store the bottle in a cool, dry place at 36°F to 77°F, away from excessive heat or direct sunlight
Switching to KHINDIVI?
Here’s how to make the transition as smooth as possible once your doctor has prescribed KHINDIVI for your child
1
Ask questions
Once prescribed KHINDIVI, your doctor will provide instructions on how to give the prescribed amount. The trained professionals at Eton Cares can answer any follow-up questions
Photo is for reference only. The actual syringe may differ.
2
Become familiar with the syringe
Anovo® Specialty Pharmacy will provide an oral syringe with your KHINDIVI prescription. Follow the instructions and use the empty syringe to practice giving the prescribed dose
3
Review instructions
Review the Medication Guide that comes with your KHINDIVI prescription for essential safety information and instructions to help you use KHINDIVI safely and effectively
Stay connected with KHINDIVI
KHINDIVI on Facebook
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Treatment journey resources
Patient advocacy groups
The following patient advocacy groups offer education, resources, and support for children with adrenal insufficiency and their families. Click on the logos below to explore these organizations and find helpful tools and connections.
Dedicated to improving the lives of individuals affected by congenital adrenal hyperplasia (CAH) through support, education, and research
Provides information, education, and support to patients diagnosed with adrenal diseases and their families and caregivers and medical professionals
These organizations can provide you with the knowledge and support you need to navigate your journey with adrenal insufficiency.
Get KHINDIVI news and updates
USE AND IMPORTANT SAFETY INFORMATION
USE
KHINDIVI is a prescription medicine used in children 5 years of age and older as replacement therapy when the adrenal gland is not making enough cortisol.
Limitation of Use: KHINDIVI is not approved for increased dosing during periods of stress or acute events. Use a different hydrocortisone-containing drug product for stress dosing.
IMPORTANT SAFETY INFORMATION
Always give KHINDIVI exactly as your doctor has directed.
Do not take KHINDIVI if you are allergic to hydrocortisone or any of its other ingredients.
Adrenal Crisis: Giving too low a dose or stopping medication can cause low levels of cortisol, which can result in serious illness or death. Treatment with intravenous hydrocortisone should be started immediately. When switching from another type of hydrocortisone to KHINDIVI, watch your child closely for any changes. During periods of stress such as infections or after surgery, your doctor should switch to another oral hydrocortisone product and increase the dose.
Systemic Adverse Reactions Due to Inactive Ingredients
Hyperosmolarity: KHINDIVI is not approved in children less than 5 years of age. The inactive ingredients in KHINDIVI can cause dangerous fluid imbalances.
Metabolic Acidosis and Other Adverse Reactions: Some ingredients in KHINDIVI may cause a build-up of acid in the body, low blood sugar, or injuries to the liver, kidneys, or brain, that may increase the risk of adrenal crisis.
Laxative Effects Due to Inactive Ingredients: Some ingredients in KHINDIVI may cause stomach upset resulting in vomiting and/or diarrhea and could increase the risk of adrenal crises in patients.
Immunosuppression and Increased Risk of Infection With Use of a Dosage Greater Than Replacement: Use of a greater than replacement dosage can suppress the immune system and increase the risks of new infections. Contact your health care provider if any infections develop.
Growth Retardation: The long-term use of corticosteroids in high doses may cause growth retardation in children.
Decrease in Bone Density: Corticosteroids can affect your child’s bone growth and strength.
Cushing’s Syndrome Due to High Doses of Corticosteroids: Treatment with high doses of corticosteroids can cause Cushing’s Syndrome. Treatment should be limited to the smallest dose required, and your child’s growth and development monitored appropriately.
Psychiatric Changes: Corticosteroids can change your child’s behavior or mood. Tell your doctor if your child has periods of extreme happiness, extreme sadness, hallucinations, or depression.
Changes in Vision: Tell your doctor if your child has blurred vision or other vision problems during treatment with KHINDIVI.
Gastrointestinal Adverse Reactions: Tell the doctor if your child has stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of ulcers or tears in the stomach or intestines. Taking anti-inflammatory nonsteroidal drugs, like ibuprofen, naproxen, or aspirin, can increase the risk of ulcers or tears.
The most common side effects of KHINDIVI include retaining fluids, changes in glucose tolerance, high blood pressure, behavioral and mood changes, greater appetite, and weight gain.
Vaccination: Administration of live vaccines may be acceptable in KHINDIVI-treated pediatric patients with adrenocortical insufficiency who receive replacement corticosteroids.
Please visit KHINDIVI.com/patient for more information.
You are encouraged to report negative side effects of prescription drugs by contacting Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
Please see full Prescribing Information for more information.
USE AND IMPORTANT SAFETY INFORMATION
USE
KHINDIVI is a prescription medicine used in children 5 years of age and older as replacement therapy when the adrenal gland is not making enough cortisol.
Limitation of Use: KHINDIVI is not approved for increased dosing during periods of stress or acute events. Use a different hydrocortisone-containing drug product for stress dosing.
IMPORTANT SAFETY INFORMATION
Always give KHINDIVI exactly as your doctor has directed.
Do not take KHINDIVI if you are allergic to hydrocortisone or any of its other ingredients.
Adrenal Crisis: Giving too low a dose or stopping medication can cause low levels of cortisol, which can result in serious illness or death. Treatment with intravenous hydrocortisone should be started immediately. When switching from another type of hydrocortisone to KHINDIVI, watch your child closely for any changes. During periods of stress such as infections or after surgery, your doctor should switch to another oral hydrocortisone product and increase the dose.
Systemic Adverse Reactions Due to Inactive Ingredients
Hyperosmolarity: KHINDIVI is not approved in children less than 5 years of age. The inactive ingredients in KHINDIVI can cause dangerous fluid imbalances.
Metabolic Acidosis and Other Adverse Reactions: Some ingredients in KHINDIVI may cause a build-up of acid in the body, low blood sugar, or injuries to the liver, kidneys, or brain, that may increase the risk of adrenal crisis.
Laxative Effects Due to Inactive Ingredients: Some ingredients in KHINDIVI may cause stomach upset resulting in vomiting and/or diarrhea and could increase the risk of adrenal crises in patients.
Immunosuppression and Increased Risk of Infection With Use of a Dosage Greater Than Replacement: Use of a greater than replacement dosage can suppress the immune system and increase the risks of new infections. Contact your health care provider if any infections develop.
Growth Retardation: The long-term use of corticosteroids in high doses may cause growth retardation in children.
Decrease in Bone Density: Corticosteroids can affect your child’s bone growth and strength.
Cushing’s Syndrome Due to High Doses of Corticosteroids: Treatment with high doses of corticosteroids can cause Cushing’s Syndrome. Treatment should be limited to the smallest dose required, and your child’s growth and development monitored appropriately.
Psychiatric Changes: Corticosteroids can change your child’s behavior or mood. Tell your doctor if your child has periods of extreme happiness, extreme sadness, hallucinations, or depression.
Changes in Vision: Tell your doctor if your child has blurred vision or other vision problems during treatment with KHINDIVI.
Gastrointestinal Adverse Reactions: Tell the doctor if your child has stomach pain, upset stomach, black, tarry stools, or vomiting of blood. These could be signs of ulcers or tears in the stomach or intestines. Taking anti-inflammatory nonsteroidal drugs, like ibuprofen, naproxen, or aspirin, can increase the risk of ulcers or tears.
The most common side effects of KHINDIVI include retaining fluids, changes in glucose tolerance, high blood pressure, behavioral and mood changes, greater appetite, and weight gain.
Vaccination: Administration of live vaccines may be acceptable in KHINDIVI-treated pediatric patients with adrenocortical insufficiency who receive replacement corticosteroids.
Please visit KHINDIVI.com/patient for more information.
You are encouraged to report negative side effects of prescription drugs by contacting Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at www.fda.gov/safety/medwatch or call 1-800-FDA-1088.
Please see full Prescribing Information for more information.